
The Baton Rouge Clinic
Baton Rouge, LA
A "naked" neurotoxin with no accessory proteins.

Baton Rouge, LA

Annapolis, MD

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Xeomin (incobotulinumtoxinA) is a botulinum toxin type A made by Merz, formulated without the complexing proteins found in other brands, which is why it's called a "naked" toxin. It's FDA-approved for frown lines, forehead lines and crow's feet plus several medical conditions, onsets in about 3 to 4 days, and lasts 3 to 4 months.
The purified formulation is Xeomin's main selling point. Because it contains only the active neurotoxin, there is theoretically less protein for the immune system to react to, which may lower the chance of developing neutralizing antibodies over years of treatment. That matters mostly for patients on high doses for medical conditions, and it is why Xeomin is sometimes tried when someone appears to have stopped responding to another toxin, though evidence for that switch is limited. Xeomin units are roughly interchangeable with Botox units, close to 1:1, unlike Dysport. It also doesn't need refrigeration before reconstitution. Cosmetically, most patients cannot tell the difference between brands. Since July 2024 Xeomin has also been approved for forehead lines and crow's feet, making it the only toxin cleared to treat all three upper-face areas in one session.
Xeomin lasts about 3-4 months, the same as Botox. It starts working in 3-4 days and reaches full effect around two weeks. Xeomin is the only neurotoxin FDA-approved for all three upper-face areas (frown lines, forehead lines, and crow's feet) as of July 2024.
Xeomin is "naked" toxin: incobotulinumtoxinA, purified free of the accessory proteins the other brands carry. In theory, less foreign protein means a lower chance of developing neutralizing antibodies over years of treatment. In practice, antibody resistance is uncommon with any modern toxin at cosmetic doses, and head-to-head duration is essentially identical to Botox, so don't expect Xeomin to last longer. Your actual duration depends on dose, muscle strength, metabolism, exercise, and how long you've been treated; long-term users often stretch further as muscles weaken. If your Xeomin consistently fades by 6-8 weeks, under-dosing is a likelier explanation than resistance. A practical quirk: Xeomin doesn't need refrigeration before reconstitution, which matters to clinics, not to your result.
Xeomin's common side effects are mild and local: injection-site pain, bruising and swelling, headache, and occasionally a temporary droopy eyelid or brow, dry eye, or eyelid swelling. Most resolve within days to weeks. Xeomin carries the same FDA boxed warning as other botulinum toxins for distant spread of toxin effect.
Droop happens when product reaches the eyelid levator muscle or over-relaxes the forehead. It isn't reversible and fades as the toxin wears off over 3-4 months, though apraclonidine drops can partially lift a droopy lid in the meantime. Because Xeomin contains no complexing proteins, it may carry a theoretically lower risk of neutralizing antibodies: relevant mainly to people treated frequently or at high therapeutic doses, not to the average cosmetic patient. Xeomin isn't used in pregnancy or breastfeeding, in neuromuscular disorders like myasthenia gravis, Lambert-Eaton syndrome, or ALS, or over an active skin infection. Seek immediate medical care for difficulty swallowing, speaking, or breathing, or new muscle weakness anywhere in the body: rare at cosmetic doses, but the reason for the boxed warning.
After Xeomin: stay upright for 4 hours, don't rub or massage the treated area for 24 hours, and avoid strenuous exercise, saunas, hot tubs, and alcohol for 24 hours. Normal facial expression is fine. Onset is 3-4 days, with full effect by about two weeks.
The purpose of these rules is to keep the toxin where it was placed until it binds to the nerve endings: displacement is what causes an unintended droopy lid or heavy brow. Skip facials, microneedling, laser, and massage over the treated area for two weeks, and avoid head-down positions like yoga inversions or face-down massage on day one. Makeup is fine after a few hours if applied gently. Ice helps bruising. Judge your result at 14 days, not sooner: deciding it "didn't work" at day four is the most common mistake, and any touch-up belongs at the two-week mark. Xeomin's lack of refrigeration requirement before reconstitution changes nothing about aftercare. Report drooping or double vision, and seek urgent care for swallowing or breathing difficulty.
Xeomin typically costs $10 to $18 per unit in the US, and its units are dosed one-to-one with Botox units. A frown-line treatment of about 20 units usually runs $200 to $360, and a full upper face runs roughly $350 to $800. Prices vary by market.
Xeomin is often priced slightly below Botox per unit, though the gap is small in most markets and some clinics price them identically. Two pricing models exist: per unit, which is more transparent, and per area or flat fee, which can obscure how much product you actually received. Always ask for your unit count. Cost is driven by your metro area (major coastal cities sit at the top of the range), injector credentials, and how much product your muscles need; strong glabellar muscles may require 25 units or more. Cosmetic Xeomin is not covered by insurance. Manufacturer rewards programs and clinic memberships can reduce the effective price. These are typical 2026 ranges, not fixed or guaranteed prices.